��ࡱ� > �� � � ���� � � � � � � ������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������ '` �R� � bjbj{P{P 8\ : : � �� �� �� � z z z z z z z � v� v� v� v� \ ү � � e( � z� z� z� z� z� z� z� z� ' ' ' ' ' ' ' W) h �+ > ' z �� z� z� �� �� ' z z z� z� ( �� z z� z z� ' �� ' z z z� n� @�S���� v� � ( � 5( 0 e( �+ � �+ �+ z ( z� r �� �� � �� z� z� z� ' ' � z� z� z� e( �� �� �� �� � � � �s 2w D7 � � � 2w � � � z z z z z z ���� Program BIT's 1 st Annual International Conference of Medichem-2010 Theme: Smart Chemistry in Drug Discovery Time: May 18-20, 2010 Venue: Beijing International Convention Center, Beijing, China May 17, 2010 Time Lobby of Hotel 08:00-18:00 Registration May 18, 2009 Opening Ceremony and Keynote Forum �Time �Activities �May 18, 2010 � 9:00-9:35 �Opening Ceremony �May 18, 2010 � 9:35-12:00 �Keynote & Plenary Lectures �Session Chair: Call for Host 9:35-10:05 Title: Chemical Biology Challenges for 21st Century Medicinal Chemistry�Dr. Tony Wood, Vice President, Head of Worldwide Medicinal Chemistry, Pfizer Global Research & Development, UK 10:05-10:35 Speech Opportunity Available 10:35-11:05 Title: Total Synthesis of a Calcium Pumping Activator Plakortone B and Its DiastereomersDr. Henry N.C. Wong, Pro-Vice-Chancellor /Vice-President, Head, New Asia College; Professor of Chemistry, Department of Chemistry, China 11:05-11:35 Speech Opportunity Available 11:35-12:05 Speech Opportunity Available Track 1: Target Structure and Fragment Based Drug Design and Synthesis �Time ��Track Info May 18, 2010 � 13:30-17:30 Track 1-1: Latest Breakthrough Topics Session Chair: Call for Host Co-Chair: Dr. Srinivas Odde, Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, USA 13:30-13:35 Welcome: Session Introduction 13:35-14:00 Title: Moving Beyond Rules: The Development of a Central Nervous System Multi-Parameter Optimization (CNS MPO) Tool to Enable Alignment of Drug-Like PropertiesDr. Xinjun Hou, Associate Research Fellow, Head of Neuroscience Computational Chemistry, Pfizer, Inc. USA 14:00-14:25 Title: Unprecedented Natural Product-like Scaffolds for Fragment Based Drug Design and SynthesisDr. Dmitry Genis, CEO, ASINEX, Ltd. Russia 14:25-14:50 Speech Opportunity Available 14:50-15:15 Title: Synthesis of Heteroaromatic Compounds by Oxidative Aromatization Using Activated Carbon and Molecular Oxygen SystemDr. Masahiko Hayashi, Professor, Department of Chemistry, Faculty of Science, Kobe University, Japan 15:15-15:30 Coffee Break 15:30-15:55 Title: Structure-based Design of Receptor and Enzyme Modulators. Two Case Studies in Drug Discovery and Chemical BiologyDr. Beno�t D�prez, professor of Chemistry, Faculty of Pharmacy (U. Lille2), Heads of the Department of Molecular Drug Discovery at the Institut Pasteur De Lille (Inserm U761), France 15:55-16:20 Speech Opportunity Available 16:20-16:45 Title:Computational Discovery of Novel Low Micromolar LEDGF/p75-HIV-1 Integrase Disrupting CompoundsDr. Srinivas Odde, Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, USA 16:45-17:10 Title: Production of Human Drug Metabolites via Regioselective Monooxygenation Catalyzed by Secreted Peroxygenases from Fungi Dr. Matthias Kinne, Research Associate, Junior Research Group Leader,International Graduate School of Zittau, Germany 17:10-17:30 Conclusion and Discussion May 19, 2010 � 9:00-12:00 Track 1-2: Receptors and Ion Channel Based Drug Design and Development Chair Dr. Thomas Ryckmans, Senior Principle, Pfizer Discovery Chemistry, Global Research and Development, UK �Co-Chair: Dr. Zhi-Qiang Yang, Research Fellow, Merck Research Laboratories, USA 09:00-09:05 Welcome: Session Introduction 09:05-9:25 Speech Opportunity Available 09:25-09:45 Title: A Journey in Physico-chemical Property Space, From Lead to Drug Candidates: Metrics, Challenges and Progress in Peptidergic GPCRs AntagonistsDr. Thomas Ryckmans, Senior Principle, Pfizer Discovery Chemistry, Global Research and Development, UK 09:45-10:05 Title: Synthesis and Evaluation of Potent and Selective T-type Calcium Ion-channel�Antagonists in�CNS ModelsDr. Zhi-Qiang Yang,Research Fellow, Merck Research Laboratories, USA 10:05-10:25 Title: Discovery of Muscarinic Acetylcholine Receptor Antagonists: from SBR to Hits to LeadsDr. Yonghui Wang, Manager of Medicinal Chemistry, R&D China, GlaxoSmithKline, China 10:25-10:35 Coffee Break 10:35-10:55 Title: Recent Developments on Positive Allosteric Modulators of the AMPA Receptors and Their Therapeutic PromisesDr. Bernard Pirotte,Professor, Department of Medicinal Chemistry, Drug Research Center, University of Liege, Belgium 10:55-11:15 Title: Development of a New Strategy for Cancer Therapy: Targeting Ion ChannelsDr. Annarosa Arcangeli,Professor, General Pathology and Immunology at the Department of Experimental Pathology and Oncology, the University of Firenze, Italy 11:15-11:35 Title: Interaction between Membrane Proteins and Ions Studiedby ATR-FTIR Spectroscopy: a Potential Tool for Drug ScreeningDr. Yuji Furutani, Associate Professor, Division of Biomolecular Sensing, Department of Life and Coordination-Complex Molecular Science, Institute for Molecular Science, Japan 11:35-11:55 Title: Extracellular Hsp70 as EGF Receptor TransactivatorDr. Anton L. Evdonin, Institute of Cytology RAS, Russia 11:55-12:15 Title: Multi-Parameter Analysis of EGF Receptor Pathway ActivationDr. Matthew Hsu, R&D Director, Millipore Corporation, �USA �May 19, 2010 � 13:30-17:30 Track 1-3: Enzymes/Protein Target Based Drug Design and Development Session Chair: Dr. Craig Tuerk, Professor, Biology and Chemistry, Morehead State University, USA �Co-Chair: Dr. Tim Corson, CIHR Jean-Fran�ois St-Denis Fellowship in Cancer Research, Department of Molecular, Cellular & Developmental Biology, Yale University, USA 13:30-13:35 Welcome: Session Introduction 13:35-14:00 Title: PI3Kg and PI3KdPartners in Crime in Inflammation First Comes First Serves?Dr. Thomas Ruckle, Director of Discovery Project Management at Merck Serono, Switerland 14:00-14:25 Title: Natural Product Mechanism of Action: Lessons from TriptolideDr. Tim Corson, CIHR Jean-Fran�ois St-Denis Fellowship in Cancer Research, Department of Molecular, Cellular & Developmental Biology, Yale University, USA 14:25-14: 50 Title: RNA Linking Library Presentation of Chemical Candidates for Binding to Target ProteinsDr. Craig Tuerk, Professor, Biology and Chemistry, Morehead State University, USA 14:50-15:15 Title: Potent and Selective Inhibitors of Phospholipase A2 as Novel Agents for the Treatment of Inflammatory Diseases and Neurological DisordersDr. George Kokotos, Professor of Organic Chemistry, Director of Laboratory of Organic Chemistry, University of Athens, Greece 15:15-15:30 Coffee Break 15:30-15:55 Title: Therapeutic Drug Discovery Targeting Hypoxic Cancers with Carbohydrate-based Carbonic Anhydrase InhibitorsDr. Sally-Ann Poulsen, Chief Investigator & Associate Professor, Chemical Biology Group Eskitis Institute for Cell and Molecular Therapies, Griffith University, Australia 15:55-16:20 Title: SAR Studies on Salacinol, a Potent a-glucosidase Inhibitor Isolated from Ayurvedic Traditional Medicine Salacia ReticulataDr. Osamu Muraoka, Professor, School of Pharmacy, Kinki University, Japan 16:20-16:45 Title: Paclitaxel Conjugated to Nanoparticles for Selectively Targeting Cancer CellsDr. Reuben Jih-Ru Hwu, Dean, College of Science, National Central University, Taiwan 16:45-17:10 Title: Targeting Bcl-2 Proteins for Anti-cancer TreatmentDr. Guillaume Lessene, WEHI Fellow - Laboratory Head, Medicinal Chemistry, Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, WEHI Biotech Centre, Australia 16:50-17:10 Title: Enzyme Inhibitors: Insights into Drug DesignDr. Maninder Minu, Assistant Professor, Delhi Institute of Pharmaceutical Sciences & Research, University of Delhi, India 17:10-17:30 Conclusion and Discussion ��May 20, 2010 � 9:00-12:00 Track 1-4: DNA/RNA Targeted Molecule Designs and Chemistry Session Chair: Dr. Peter E. Nielsen, Professor, Department of Cellular and Molecular Medicine, University of Copenhagen, Faculty Of Health Sciences, Denmark �Co-Chair: Call for Co-Host 09:00-09:05 Welcome: Session Introduction 09:05-09:30 Speech Opportunity Available 09:30-09:55 Title:Aptamers as Regulators of Gene Expression and Tas Probes for Imaging TumorsDr. Jean-Jacques Toulm�, Director, Inserm U869, European Institute of Chemistry and Biology, University of Bordeaux, France 09:55-10:20 Title: Towards Novel Gene Targeted Drugs - Progress in Delivery of Peptide Nucleic Acid (PNA) Dr. Peter E. Nielsen,Professor, Department of Cellular and Molecular Medicine, University of Copenhagen, Faculty Of Health Sciences, Denmark 10:20-10:35 Coffee Break 10:35-11:00 Title: Targeting Alternative DNA/RNA StructuresDr. Jean-Louis Mergny, Research Director, European Institute of Chemistry and Biology, INSERM U869, France 11:00-11:25 Title: Pyrrole-imidazole Polyamide Conjugate as an Artificial Genetic SwitchDr. Hiroshi Sugiyama, Professor, Department of Chemistry, Graduate School of Science, Kyoto University, Japan 11:25-11:50 Title: �DNA Photocleavage by DNA/LNA and PNA ConjugatesDr. Eylon Yavin, Assistant Professor, The Institute for Drug Research, The School of Pharmacy, Hebrew University of Jerusalem, Israel 11:50-12:00 Conclusion and Discussion ��May 18, 2010 13:30-17:30 Track 1-5: Fragment-based�Approaches�in�Drug�Discovery � Session Chair: Dr. Hongmao Sun, Senior Principal Scientist, Discovery Chemistry, Hoffmann-La Roche Inc., USA �Co-Chair: Dr. MeihuaTu, Senior Principal Scientist, CVMED Chemistry, Pfizer Global Research & Development in Groton, USA 13:30-13:35 Welcome: Session Introduction 13:35-14:00 Speech Opportunity Available 14:00-14:25 Title: A Yoctoliter-scale DNA Reactor for Small-molecule EvolutionDr. Nils Jakob Vest Hansen, CEO, Vipergen I n c . , D e n m a r k 1 4 : 2 5 - 1 4 : 5 0 T i t l e : S m a l l S t r u c t u r a l U n i t s f o r C o m p o u n d P r o p e r t y M o d u l a t i o n i n D r u g D i s c o v e r y D r . K l a u s M � l l e r , P r o f e s s o r , P h a r m a c e u t i c a l R e s e a r c h , F . H o f f m a n n L a - R o c h e A G , S w i t z e r l a n d � 1 4 : 5 0 - 1 5 : 1 5 T i t l e : F r a g m e n t s o f L i f e "!, a M e t a b o l o m e -Inspired Fragment Library for FBDD Targeting Infectious DiseaseDr. Lance Stewart, CEO, Emerald BioStructures, Inc.,USA 15:15-15:30 Coffee Break 15:30-15:55 Title: De Novo Design of Potent BCL-xl Inhibitors by Scaffold Hopping and Data MiningDr. Hongmao Sun, Senior Principal Scientist, Discovery Chemistry, Hoffmann-La Roche Inc., USA 15:55-16:20 Title: Fragment-based Dynamic Combinatorial Library for Rapid Hit GenerationDr. Beining Chen, Department of Chemistry, University of Sheffield, UK 16:20-16:45 Title: Fragment-based Design through Shape and Electrostatics: all the Right Moves?Dr. Paul C. D. Hawkins, �OpenEye Scientific Software, USA 16:45-17:10 Title: Beyond Fragments � what do we do? Dr. Michael Shapiro, Associate Professor, Department of Pharmaceutical Sciences, University of Maryland, USA 17:10-17:30 Conclusion and Discussion Track 2: Application of New Technologies and Tools for Medichem Studies �Time �Track Info May 18, 2010 � 13:30-17:30 Track 2-1: Virtual Screening t o C o m b i n a t o r i a l C h e m i s t r y f o r H i t F i n d i n g s �P a r t 1 � � � S e s s i o n C h a i r : D r . B e r t h o G i l d a s , R e s e a r c h T e a m M a n a g e r &